5-Amino-1MQ Compound Reference
Published · Last updated · Publisher: ENOS Labs USA
What is 5-Amino-1MQ?
5-Amino-1MQ is a small quaternary quinolinium compound, not a peptide, that inhibits the enzyme nicotinamide N-methyltransferase (NNMT). A 2018 mouse study reported effects on diet induced obesity, and later mouse work examined aged muscle stem cells. All published evidence is preclinical, and it is not an approved drug.
- Synonyms
- 5-Amino-1-methylquinolinium; NNMT inhibitor 5-amino-1MQ
- Classification
- Small molecule inhibitor of nicotinamide N-methyltransferase (not a peptide)
What is 5-Amino-1MQ?
5-Amino-1MQ was identified in a structure guided search for selective, membrane permeable NNMT inhibitors.
Research context
Studies examine fat tissue metabolism in diet induced obese mice, combination with calorie restriction, and regenerative capacity of aged muscle.
Mechanisms being investigated
- Inhibition of NNMT, an enzyme that methylates nicotinamide and is linked to NAD+ and methyl donor balance.
Research status
Approval status: Not approved for human use. Highest evidence tier in the cited literature: preclinical.
Preclinical. Not approved for any use; no published human trials.
Established findings
- NNMT inhibition in enzyme and cell assays.
Preliminary or experimental findings
- Metabolic and muscle findings from mice.
Chemical reference information
| Molecular formula | C10H11N2+ |
|---|---|
| Molecular weight | 159.21 g/mol (cation) |
| CAS number | 685079-15-6 |
| PubChem CID | 950107 |
Values taken from the PubChem record. Supplied as a salt; the counterion changes the weight per mole of material.
Testing considerations
- Small molecule: identity by MS or NMR, purity by HPLC; confirm the counterion and salt form.
General methods are explained in purity versus identity testing.
What is still unknown
- Human pharmacology and safety.
Related resources
ENOS catalog listing: 5-Amino-1MQ 50MG
Research use limitations
This page summarizes published research and regulatory status. It is not medical advice and does not describe any use in people. Material supplied by ENOS Labs USA is for in-vitro laboratory research only and is not a drug product, even where a related drug has been approved.
To continue, see mitochondrial peptide research, how to read a certificate of analysis, why purity and identity are separate tests, the compound directory and the peptide testing glossary.
References
Each source below was opened and checked against its PubMed, ClinicalTrials.gov or PubChem record. Links open in a new tab.
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice (PMID 29155147)Biochemical Pharmacology, 2018 · PubMed
- Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle (PMID 30753815)Biochemical Pharmacology, 2019 · PubMed
- Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice (PMID 33707534)Scientific Reports, 2021 · PubMed
- 5-Amino-1-methylquinolinium compound record (PubChem CID 950107)PubChem · NIH National Library of Medicine
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