NAD+ Compound Reference
Published · Last updated · Publisher: ENOS Labs USA
What is NAD+?
NAD+ is nicotinamide adenine dinucleotide, a cofactor every cell uses to carry electrons in energy metabolism and as a substrate for enzymes such as sirtuins and PARPs. It is not a peptide. Research links falling tissue NAD+ to aging in model organisms. NAD+ supplied for laboratory use is not an approved drug.
- Synonyms
- Nicotinamide adenine dinucleotide; Oxidized NAD; beta-NAD
- Classification
- Dinucleotide redox cofactor (not a peptide)
What is NAD+?
NAD+ is the oxidized form of the NAD+/NADH redox pair, built from nicotinamide mononucleotide and adenosine monophosphate.
Research context
Reviews cover NAD+ biosynthesis and salvage, its decline with age in animal tissues, and its roles in mitochondrial metabolism, DNA repair and signaling.
Mechanisms being investigated
- Electron carrier in glycolysis and oxidative phosphorylation.
- Substrate for sirtuins, PARPs and CD38.
Research status
Approval status: Not approved for human use. Highest evidence tier in the cited literature: preclinical and early human.
Not approved as a drug for any use. Human studies have mostly examined NAD+ precursors rather than NAD+ itself.
Established findings
- Its central role as a redox cofactor and enzyme substrate.
- Age related decline in several animal tissues.
Preliminary or experimental findings
- Whether raising NAD+ changes aging related outcomes in humans.
Chemical reference information
| Molecular formula | C21H27N7O14P2 |
|---|---|
| Molecular weight | 663.4 g/mol |
| CAS number | 53-84-9 |
| PubChem CID | 5892 |
Values taken from the PubChem record.
Testing considerations
- Small molecule: identity by MS or NMR and purity by HPLC; NADH and degradation products such as nicotinamide are the usual impurities.
- Sensitive to heat and light in solution.
General methods are explained in purity versus identity testing.
What is still unknown
- Human relevance of animal NAD+ decline findings.
Related resources
ENOS catalog listing: NAD+ 500MG
Research use limitations
This page summarizes published research and regulatory status. It is not medical advice and does not describe any use in people. Material supplied by ENOS Labs USA is for in-vitro laboratory research only and is not a drug product, even where a related drug has been approved.
To continue, see mitochondrial peptide research, how to read a certificate of analysis, why purity and identity are separate tests, the compound directory and the peptide testing glossary.
References
Each source below was opened and checked against its PubMed, ClinicalTrials.gov or PubChem record. Links open in a new tab.
- NAD+ in aging, metabolism, and neurodegeneration (PMID 26785480)Science, 2015 · PubMed
- NAD(+) metabolism and its roles in cellular processes during ageing (PMID 33353981)Nature Reviews Molecular Cell Biology, 2021 · PubMed
- Nicotinamide adenine dinucleotide compound record (PubChem CID 5892)PubChem · NIH National Library of Medicine
These products are sold strictly for in-vitro laboratory research and are not intended for human consumption, diagnosis, treatment, or any therapeutic use. Purchaser must be 18 years of age or older and confirms they are a qualified researcher.